Retatrutide is a novel triple agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 and glucagon receptors. Phase 2 clinical trial results published in The New England Journal of Medicine show retatrutide achieved up to 17.5% mean weight reduction at 24 weeks in adults with obesity and overweight. In a secondary endpoint, retatrutide demonstrated a mean weight reduction up to 24.2% at 48 weeks.
Specification: 5mg/ 10mg/ 15mg/ 20mg
CAS No.: 2381089-83-2
Formula: C221H342N46O68
Molar mass: 4731.33
Purity: >99%
Test Result |
Tests | Specifications | Results |
Appearance | White powder | Conforms |
Solubility | Freely soluble in water | Conforms |
Purity(HPLC) | ¡Ý99.0% | 99.24% |
Solubility(water) | ¡Ý30mg/ml | Conforms |
Sodium | <5.0% | 1.19% |
Peptide Content | ¡Ý85.0% | 90.63% |
Water Content (Karl Fischer) | ¡Ü10.0% | 3.77% |
Residual solvents | Acetonitrile NMT 410ppm Methanol NMT 3000ppm | Conforms Conforms |
Bacterial endotoxins | <10EU/mg | Conforms |
Microbial Limits | Total aerobic microbial count ¡Ü200cfu/g Total yeast and mold count ¡Ü200cfu/g | Conforms Conforms |
MS(ESI) | 4113.64¡À1.0 | 4113.38 |
Assay(HPLC) | 95.0~105.0%(on anhydrous and salt-free substance basis) | 100.57% |
PH(5.0MG/ML) | 7.0-7.5 | 7.43 |
Anti-obesity
Retatrutide works in the treatment of obesity by targeting three different hunger regulating hormones:
- GIP (gastric inhibitory peptide or glucose-dependent insulinotropic polypeptide) is an incretin hormone that is released from the gut after eating. It stimulates the beta-cells in the pancreas to secrete insulin.
- GLP-1 (glucagon-like peptide-1) is also an incretin hormone that stimulates the beta-cells to secrete insulin.
- glucagon is a hormone secreted from the alpha-cells in the pancreas. It stimulates glucose production in the liver and helps maintain adequate plasma glucose concentrations.
The drug has been nicknamed 'triple G' because it is an agonist of all three receptors.
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